Drug interactions
Fenoprofen + Sulindac
Severity: Major
Fenoprofen and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together increases the risk of gastrointestinal ulceration and bleeding, renal impairment and fluid retention without added benefit.
What this interaction means in plain words
Fenoprofen and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Sulindac belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition reduces gastroprotective and renal prostaglandins and impairs platelet function.
What to do
Avoid combining systemic NSAIDs and use a single agent at the lowest effective dose. Monitor for GI bleeding and renal function if concurrent use cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Fenoprofen with Sulindac?
MediHelp rates the interaction as major. Fenoprofen and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Taking two NSAIDs together increases the risk of gastrointestinal ulceration and bleeding, renal impairment and fluid retention without added benefit.
How serious is the interaction between Fenoprofen and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining systemic NSAIDs and use a single agent at the lowest effective dose. Monitor for GI bleeding and renal function if concurrent use cannot be avoided.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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