Drug interactions
Fenoprofen + Ticagrelor
Severity: Major
Fenoprofen and Ticagrelor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs combined with ticagrelor increase the risk of bleeding, especially gastrointestinal bleeding. This is of particular concern in patients also taking aspirin.
What this interaction means in plain words
Fenoprofen and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Ticagrelor belongs to Cardiovascular.
Why it happens
Additive platelet inhibition by ticagrelor and NSAID-mediated platelet dysfunction plus mucosal injury.
What to do
Avoid regular NSAID use with ticagrelor and use paracetamol where possible. If unavoidable, add gastroprotection and monitor for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Fenoprofen with Ticagrelor?
MediHelp rates the interaction as major. Fenoprofen and Ticagrelor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs combined with ticagrelor increase the risk of bleeding, especially gastrointestinal bleeding. This is of particular concern in patients also taking aspirin.
How serious is the interaction between Fenoprofen and Ticagrelor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use with ticagrelor and use paracetamol where possible. If unavoidable, add gastroprotection and monitor for bleeding.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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