Drug interactions
Fenoprofen + Tolazamide
Severity: Moderate
Fenoprofen and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the glucose lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is variable and more likely with highly protein-bound NSAIDs and in renal impairment.
What this interaction means in plain words
Fenoprofen and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding and reduced renal clearance; the mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping fenoprofen and reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Fenoprofen with Tolazamide?
MediHelp rates the interaction as moderate. Fenoprofen and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the glucose lowering effect of sulfonylureas and occasionally cause hypoglycemia. The effect is variable and more likely with highly protein-bound NSAIDs and in renal impairment.
How serious is the interaction between Fenoprofen and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping fenoprofen and reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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