Drug interactions
Fenoprofen + Vancomycin
Severity: Moderate
Fenoprofen and Vancomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce vancomycin clearance and add to nephrotoxic risk. This has been described mainly in neonates, but renal injury is also a concern in adults with other risk factors.
What this interaction means in plain words
Fenoprofen and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fenoprofen belongs to Musculoskeletal; Vancomycin belongs to Anti Bacterial.
Why it happens
NSAID-induced reduction in renal prostaglandins and glomerular filtration decreases vancomycin elimination.
What to do
Monitor creatinine and vancomycin trough or AUC levels and adjust the dose. Avoid the NSAID in neonates and patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Fenoprofen with Vancomycin?
MediHelp rates the interaction as moderate. Fenoprofen and Vancomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce vancomycin clearance and add to nephrotoxic risk. This has been described mainly in neonates, but renal injury is also a concern in adults with other risk factors.
How serious is the interaction between Fenoprofen and Vancomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor creatinine and vancomycin trough or AUC levels and adjust the dose. Avoid the NSAID in neonates and patients with renal impairment.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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