Drug interactions
Fenoprofen + Warfarin
Severity: Major
Fenoprofen and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen raises the risk of bleeding in patients taking warfarin, including gastrointestinal haemorrhage. Platelet inhibition and mucosal injury contribute independently of the INR, and some NSAIDs may also increase warfarin effect.
What this interaction means in plain words
Fenoprofen and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fenoprofen belongs to Musculoskeletal; Warfarin belongs to Cardiovascular.
Why it happens
NSAID platelet inhibition and gastric mucosal damage add to the anticoagulant effect of warfarin, with possible protein binding displacement.
What to do
Avoid the combination if possible and use paracetamol or another alternative. If it is necessary, monitor INR and bleeding signs closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Fenoprofen with Warfarin?
MediHelp rates the interaction as major. Fenoprofen and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fenoprofen raises the risk of bleeding in patients taking warfarin, including gastrointestinal haemorrhage. Platelet inhibition and mucosal injury contribute independently of the INR, and some NSAIDs may also increase warfarin effect.
How serious is the interaction between Fenoprofen and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use paracetamol or another alternative. If it is necessary, monitor INR and bleeding signs closely and consider gastroprotection.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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