Drug interactions
Fentanyl + Fosinopril-hydrochlorothiazide
Severity: Minor
Fentanyl and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can lower blood pressure and may cause orthostatic hypotension, adding to the effect of an ACE inhibitor and thiazide. Opioid-related antidiuretic hormone release and urinary retention may also reduce diuretic effect.
What this interaction means in plain words
Fentanyl and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypotension, plus opioid-induced ADH release and urinary retention that oppose diuresis.
What to do
Monitor blood pressure, fluid status and urine output, especially at opioid initiation or dose increases. Adjust the diuretic if edema or retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Fentanyl and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can lower blood pressure and may cause orthostatic hypotension, adding to the effect of an ACE inhibitor and thiazide. Opioid-related antidiuretic hormone release and urinary retention may also reduce diuretic effect.
How serious is the interaction between Fentanyl and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output, especially at opioid initiation or dose increases. Adjust the diuretic if edema or retention develops.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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