Drug interactions
Fentanyl + Guselkumab
Severity: Minor
Fentanyl and Guselkumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 enzyme expression through raised cytokines. Guselkumab treatment may normalize this, potentially increasing CYP3A4 activity and lowering fentanyl exposure. The effect is theoretical and likely small.
What this interaction means in plain words
Fentanyl and Guselkumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Guselkumab belongs to Miscellaneous.
Why it happens
Reversal of cytokine-mediated CYP3A4 suppression may modestly increase fentanyl metabolism.
What to do
No routine dose change is needed. Monitor analgesic response when guselkumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Fentanyl with Guselkumab?
MediHelp rates the interaction as minor. Fentanyl and Guselkumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 enzyme expression through raised cytokines. Guselkumab treatment may normalize this, potentially increasing CYP3A4 activity and lowering fentanyl exposure. The effect is theoretical and likely small.
How serious is the interaction between Fentanyl and Guselkumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor analgesic response when guselkumab is started or stopped.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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