Drug interactions
Fentanyl + Isavuconazonium
Severity: Major
Fentanyl and Isavuconazonium: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise fentanyl concentrations. This may cause prolonged sedation and respiratory depression.
What this interaction means in plain words
Fentanyl and Isavuconazonium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fentanyl belongs to Musculoskeletal; Isavuconazonium belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated fentanyl metabolism by isavuconazole.
What to do
Monitor for respiratory depression and sedation and reduce the fentanyl dose as needed. Reassess when isavuconazonium is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Fentanyl with Isavuconazonium?
MediHelp rates the interaction as major. Fentanyl and Isavuconazonium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isavuconazole, the active moiety of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise fentanyl concentrations. This may cause prolonged sedation and respiratory depression.
How serious is the interaction between Fentanyl and Isavuconazonium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for respiratory depression and sedation and reduce the fentanyl dose as needed. Reassess when isavuconazonium is stopped.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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