Drug interactions
Fentanyl + Lemborexant
Severity: Moderate
Fentanyl and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause CNS depression, so combined use increases sedation and psychomotor impairment. Next-day drowsiness and falls are of particular concern.
What this interaction means in plain words
Fentanyl and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonism and orexin receptor antagonism.
What to do
Use the lowest effective lemborexant dose and warn patients about impaired alertness and driving. Monitor for excessive sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Fentanyl with Lemborexant?
MediHelp rates the interaction as moderate. Fentanyl and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause CNS depression, so combined use increases sedation and psychomotor impairment. Next-day drowsiness and falls are of particular concern.
How serious is the interaction between Fentanyl and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and warn patients about impaired alertness and driving. Monitor for excessive sedation and respiratory depression.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
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