Drug interactions
Fentanyl + Oliceridine
Severity: Major
Fentanyl and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are potent mu-opioid agonists, so concurrent use produces additive analgesia and respiratory depression. Excess sedation and overdose may occur.
What this interaction means in plain words
Fentanyl and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fentanyl belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive mu-opioid receptor agonism leads to pharmacodynamic CNS and respiratory depression.
What to do
Avoid unless needed, using the lowest effective doses with the total opioid exposure considered. Monitor respiratory rate, oxygen saturation and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Fentanyl with Oliceridine?
MediHelp rates the interaction as major. Fentanyl and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are potent mu-opioid agonists, so concurrent use produces additive analgesia and respiratory depression. Excess sedation and overdose may occur.
How serious is the interaction between Fentanyl and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless needed, using the lowest effective doses with the total opioid exposure considered. Monitor respiratory rate, oxygen saturation and sedation.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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