Drug interactions
Fentanyl + Pexidartinib
Severity: Major
Fentanyl and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib induces CYP3A4, which can lower fentanyl concentrations and reduce analgesia. Withdrawal symptoms may emerge, and if the inducer is stopped, fentanyl levels can rise and cause toxicity.
What this interaction means in plain words
Fentanyl and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fentanyl belongs to Musculoskeletal; Pexidartinib belongs to Oncology.
Why it happens
CYP3A4 induction by pexidartinib increases fentanyl clearance.
What to do
Avoid if possible; otherwise monitor pain control and withdrawal and titrate fentanyl as needed. On stopping pexidartinib, reduce the fentanyl dose and watch for respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Fentanyl with Pexidartinib?
MediHelp rates the interaction as major. Fentanyl and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib induces CYP3A4, which can lower fentanyl concentrations and reduce analgesia. Withdrawal symptoms may emerge, and if the inducer is stopped, fentanyl levels can rise and cause toxicity.
How serious is the interaction between Fentanyl and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor pain control and withdrawal and titrate fentanyl as needed. On stopping pexidartinib, reduce the fentanyl dose and watch for respiratory depression.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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