Drug interactions
Fentanyl + Prasugrel
Severity: Moderate
Fentanyl and Prasugrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gastric emptying, which delays and lowers absorption of oral prasugrel and the formation of its active metabolite. Platelet inhibition may therefore be delayed or reduced in the early period after a loading dose, which matters in acute coronary syndrome and PCI.
What this interaction means in plain words
Fentanyl and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Prasugrel belongs to Cardiovascular.
Why it happens
Opioid-induced delay in gastric emptying reduces and slows the absorption of prasugrel's active metabolite.
What to do
In acute coronary syndrome patients who need an opioid, consider a parenteral antiplatelet agent instead of relying on oral prasugrel. Otherwise monitor for inadequate antiplatelet effect after the loading dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fentanyl and Prasugrel, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Prasugrel
Frequently asked questions
Can I take Fentanyl with Prasugrel?
MediHelp rates the interaction as moderate. Fentanyl and Prasugrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gastric emptying, which delays and lowers absorption of oral prasugrel and the formation of its active metabolite. Platelet inhibition may therefore be delayed or reduced in the early period after a loading dose, which matters in acute coronary syndrome and PCI.
How serious is the interaction between Fentanyl and Prasugrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In acute coronary syndrome patients who need an opioid, consider a parenteral antiplatelet agent instead of relying on oral prasugrel. Otherwise monitor for inadequate antiplatelet effect after the loading dose.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
