Drug interactions
Fentanyl + Quetiapine
Severity: Moderate
Fentanyl and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is sedating and can cause orthostatic hypotension, and with fentanyl it increases CNS depression and the risk of respiratory depression. Falls and over-sedation are particular concerns in older patients.
What this interaction means in plain words
Fentanyl and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fentanyl belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension through combined histamine, adrenergic and opioid receptor effects.
What to do
Use the lowest effective doses and monitor sedation, blood pressure and respiratory rate. Take extra care in older adults and when doses are being raised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Fentanyl with Quetiapine?
MediHelp rates the interaction as moderate. Fentanyl and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is sedating and can cause orthostatic hypotension, and with fentanyl it increases CNS depression and the risk of respiratory depression. Falls and over-sedation are particular concerns in older patients.
How serious is the interaction between Fentanyl and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, blood pressure and respiratory rate. Take extra care in older adults and when doses are being raised.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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