Drug interactions
Fentanyl + Ramelteon
Severity: Minor
Fentanyl and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon can cause somnolence and dizziness, and these effects may add to those of fentanyl. Its CNS depressant effect is mild compared with sedative-hypnotics, so the clinical impact is generally limited.
What this interaction means in plain words
Fentanyl and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Ramelteon belongs to Central Nervous System.
Why it happens
Mild additive sedation from melatonin receptor agonism and opioid CNS depression.
What to do
No dose change is routinely needed. Counsel patients about additive drowsiness and monitor for excessive sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Fentanyl with Ramelteon?
MediHelp rates the interaction as minor. Fentanyl and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon can cause somnolence and dizziness, and these effects may add to those of fentanyl. Its CNS depressant effect is mild compared with sedative-hypnotics, so the clinical impact is generally limited.
How serious is the interaction between Fentanyl and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Counsel patients about additive drowsiness and monitor for excessive sedation.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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