Drug interactions
Fentanyl + Tolcapone
Severity: Minor
Fentanyl and Tolcapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolcapone is a COMT inhibitor that can cause somnolence and dizziness, which may add to fentanyl sedation. The effect is usually modest.
What this interaction means in plain words
Fentanyl and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Tolcapone belongs to Central Nervous System.
Why it happens
Possible additive sedation; no established pharmacokinetic interaction.
What to do
Be aware of additive drowsiness and counsel patients on driving and machinery. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Tolcapone
- Isocarboxazid + Tolcapone Contraindicated
- Phenelzine + Tolcapone Contraindicated
- Tolcapone + Tranylcypromine Contraindicated
- Metoclopramide + Tolcapone Major
- Apomorphine + Tolcapone Moderate
- Asenapine + Tolcapone Moderate
Frequently asked questions
Can I take Fentanyl with Tolcapone?
MediHelp rates the interaction as minor. Fentanyl and Tolcapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolcapone is a COMT inhibitor that can cause somnolence and dizziness, which may add to fentanyl sedation. The effect is usually modest.
How serious is the interaction between Fentanyl and Tolcapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of additive drowsiness and counsel patients on driving and machinery. No routine dose adjustment is needed.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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