Drug interactions
Fentanyl + Ustekinumab
Severity: Minor
Fentanyl and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is cleared by CYP3A4, and restoration of CYP activity after cytokine blockade might theoretically lower its exposure. No clinically important effect has been established.
What this interaction means in plain words
Fentanyl and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Ustekinumab belongs to Gastrointestinal Tract.
Why it happens
Theoretical normalization of cytokine-suppressed CYP3A4 activity.
What to do
Monitor analgesic response when ustekinumab is started or stopped and adjust fentanyl dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Fentanyl with Ustekinumab?
MediHelp rates the interaction as minor. Fentanyl and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl is cleared by CYP3A4, and restoration of CYP activity after cytokine blockade might theoretically lower its exposure. No clinically important effect has been established.
How serious is the interaction between Fentanyl and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response when ustekinumab is started or stopped and adjust fentanyl dose if needed.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
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