Drug interactions
Fentanyl + Vonoprazan
Severity: Minor
Fentanyl and Vonoprazan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor and may slightly raise fentanyl exposure. The effect is generally small but may add to opioid sedation.
What this interaction means in plain words
Fentanyl and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fentanyl belongs to Musculoskeletal; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition reduces fentanyl clearance.
What to do
Monitor for excess sedation or respiratory depression, particularly at the start of vonoprazan, and adjust the fentanyl dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Fentanyl with Vonoprazan?
MediHelp rates the interaction as minor. Fentanyl and Vonoprazan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vonoprazan is a weak CYP3A inhibitor and may slightly raise fentanyl exposure. The effect is generally small but may add to opioid sedation.
How serious is the interaction between Fentanyl and Vonoprazan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation or respiratory depression, particularly at the start of vonoprazan, and adjust the fentanyl dose if needed.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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