Drug interactions
Fentanyl intranasal + Fosinopril-hydrochlorothiazide
Severity: Minor
Fentanyl intranasal and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl can trigger antidiuretic hormone release and may reduce diuretic effect. It can also cause hypotension, adding to antihypertensive effects.
What this interaction means in plain words
Fentanyl intranasal and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release opposes diuresis, with additive hypotension.
What to do
Monitor blood pressure, fluid balance and sodium, and adjust diuretic dosing as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fentanyl intranasal with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Fentanyl intranasal and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fentanyl can trigger antidiuretic hormone release and may reduce diuretic effect. It can also cause hypotension, adding to antihypertensive effects.
How serious is the interaction between Fentanyl intranasal and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance and sodium, and adjust diuretic dosing as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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