Drug interactions
Fentanyl intranasal + Hydrochlorothiazide-losartan
Severity: Minor
Fentanyl intranasal and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can reduce diuretic response and may cause additive hypotension. Fentanyl may also cause urinary retention, which can confound diuretic effects.
What this interaction means in plain words
Fentanyl intranasal and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced antidiuretic hormone release and additive vasodilatory hypotensive effects.
What to do
Monitor blood pressure, fluid balance and urinary output, and adjust diuretic dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Fentanyl intranasal with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Fentanyl intranasal and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can reduce diuretic response and may cause additive hypotension. Fentanyl may also cause urinary retention, which can confound diuretic effects.
How serious is the interaction between Fentanyl intranasal and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance and urinary output, and adjust diuretic dose if response is reduced.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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