Drug interactions
Fentanyl intranasal + Lapatinib
Severity: Moderate
Fentanyl intranasal and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib can inhibit CYP3A4, the main enzyme that clears fentanyl, so fentanyl levels may rise. This can cause deeper sedation and respiratory depression.
What this interaction means in plain words
Fentanyl intranasal and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by lapatinib reduces fentanyl metabolism.
What to do
Monitor for sedation and respiratory depression, particularly after starting lapatinib. Reduce the fentanyl dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Fentanyl intranasal with Lapatinib?
MediHelp rates the interaction as moderate. Fentanyl intranasal and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib can inhibit CYP3A4, the main enzyme that clears fentanyl, so fentanyl levels may rise. This can cause deeper sedation and respiratory depression.
How serious is the interaction between Fentanyl intranasal and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, particularly after starting lapatinib. Reduce the fentanyl dose if needed.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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