Drug interactions
Fentanyl intranasal + Levetiracetam
Severity: Moderate
Fentanyl intranasal and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is a potent opioid causing sedation and respiratory depression, and levetiracetam may add to drowsiness. Combined use increases the risk of excessive sedation and impaired alertness.
What this interaction means in plain words
Fentanyl intranasal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from an opioid agonist and an antiepileptic.
What to do
Use the lowest effective fentanyl dose and monitor sedation and respiratory rate. Counsel on avoiding driving and other depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Fentanyl intranasal with Levetiracetam?
MediHelp rates the interaction as moderate. Fentanyl intranasal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl is a potent opioid causing sedation and respiratory depression, and levetiracetam may add to drowsiness. Combined use increases the risk of excessive sedation and impaired alertness.
How serious is the interaction between Fentanyl intranasal and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fentanyl dose and monitor sedation and respiratory rate. Counsel on avoiding driving and other depressants.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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