Drug interactions
Fentanyl intranasal + Linezolid
Severity: Major
Fentanyl intranasal and Linezolid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl has serotonergic activity and, with an MAO-inhibiting drug like linezolid, serotonin syndrome has been reported. Opioid toxicity with sedation and respiratory depression is also possible.
What this interaction means in plain words
Fentanyl intranasal and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effects of fentanyl with MAO inhibition by linezolid.
What to do
Avoid the combination if possible and use a less serotonergic analgesic such as morphine. If fentanyl is needed, titrate carefully and monitor for serotonin syndrome and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Fentanyl intranasal with Linezolid?
MediHelp rates the interaction as major. Fentanyl intranasal and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fentanyl has serotonergic activity and, with an MAO-inhibiting drug like linezolid, serotonin syndrome has been reported. Opioid toxicity with sedation and respiratory depression is also possible.
How serious is the interaction between Fentanyl intranasal and Linezolid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use a less serotonergic analgesic such as morphine. If fentanyl is needed, titrate carefully and monitor for serotonin syndrome and respiratory depression.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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