Drug interactions
Fentanyl iontophoretic transdermal system + Ramelteon
Severity: Moderate
Fentanyl iontophoretic transdermal system and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is a potent opioid that causes sedation and respiratory depression. Adding ramelteon may increase drowsiness and impair alertness.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from mu-opioid agonism and hypnotic effect.
What to do
Monitor sedation and respiratory status, particularly at treatment start. Counsel patients to avoid driving and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Ramelteon?
MediHelp rates the interaction as moderate. Fentanyl iontophoretic transdermal system and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl is a potent opioid that causes sedation and respiratory depression. Adding ramelteon may increase drowsiness and impair alertness.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, particularly at treatment start. Counsel patients to avoid driving and other sedatives.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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