Drug interactions
Fentanyl iontophoretic transdermal system + Valproic acid
Severity: Moderate
Fentanyl iontophoretic transdermal system and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fentanyl is a potent opioid and valproate is a CNS depressant, so together they may cause additive sedation and respiratory depression. The system is used in supervised hospital settings where monitoring is feasible.
What this interaction means in plain words
Fentanyl iontophoretic transdermal system and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Monitor sedation level and respiratory rate during use. Reduce the demand dose or reassess therapy if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Frequently asked questions
Can I take Fentanyl iontophoretic transdermal system with Valproic acid?
MediHelp rates the interaction as moderate. Fentanyl iontophoretic transdermal system and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fentanyl is a potent opioid and valproate is a CNS depressant, so together they may cause additive sedation and respiratory depression. The system is used in supervised hospital settings where monitoring is feasible.
How serious is the interaction between Fentanyl iontophoretic transdermal system and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate during use. Reduce the demand dose or reassess therapy if oversedation occurs.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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