Drug interactions
Fentanyl transdermal + Levetiracetam
Severity: Moderate
Fentanyl transdermal and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal fentanyl provides sustained opioid exposure with sedation and respiratory depression risk, and levetiracetam can add somnolence. The combination may deepen sedation and impair alertness.
What this interaction means in plain words
Fentanyl transdermal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression between an opioid agonist and an antiepileptic.
What to do
Monitor sedation and respiratory status, especially after dose changes. Advise against driving until stable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Fentanyl transdermal with Levetiracetam?
MediHelp rates the interaction as moderate. Fentanyl transdermal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal fentanyl provides sustained opioid exposure with sedation and respiratory depression risk, and levetiracetam can add somnolence. The combination may deepen sedation and impair alertness.
How serious is the interaction between Fentanyl transdermal and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, especially after dose changes. Advise against driving until stable.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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