Drug interactions
Fentanyl transdermal + Quinidine
Severity: Moderate
Fentanyl transdermal and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits CYP3A4 and may raise fentanyl concentrations, increasing sedation and respiratory depression risk. Slow offset of the patch prolongs any resulting toxicity.
What this interaction means in plain words
Fentanyl transdermal and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinidine inhibition of CYP3A4 reduces fentanyl clearance.
What to do
Monitor for sedation and respiratory depression and reduce the fentanyl dose if needed. Be aware that effects may persist after the patch is removed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fentanyl transdermal and Quinidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Fentanyl transdermal with Quinidine?
MediHelp rates the interaction as moderate. Fentanyl transdermal and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits CYP3A4 and may raise fentanyl concentrations, increasing sedation and respiratory depression risk. Slow offset of the patch prolongs any resulting toxicity.
How serious is the interaction between Fentanyl transdermal and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and reduce the fentanyl dose if needed. Be aware that effects may persist after the patch is removed.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
