Drug interactions
Fentanyl transdermal + Ticagrelor
Severity: Minor
Fentanyl transdermal and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A inhibitor and may modestly raise fentanyl concentrations. Because transdermal fentanyl has prolonged exposure, any increase could cause sedation or respiratory depression, though the effect is likely small.
What this interaction means in plain words
Fentanyl transdermal and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by ticagrelor reduces fentanyl clearance.
What to do
Monitor for sedation and respiratory depression, especially at initiation. Reduce fentanyl dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Fentanyl transdermal with Ticagrelor?
MediHelp rates the interaction as minor. Fentanyl transdermal and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor is a weak CYP3A inhibitor and may modestly raise fentanyl concentrations. Because transdermal fentanyl has prolonged exposure, any increase could cause sedation or respiratory depression, though the effect is likely small.
How serious is the interaction between Fentanyl transdermal and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, especially at initiation. Reduce fentanyl dose if symptoms occur.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
Full monographs, dosing and an interaction checker in the MediHelp app
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