Drug interactions
Fentanyl transmucosal + Fosinopril-hydrochlorothiazide
Severity: Minor
Fentanyl transmucosal and Fosinopril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as fentanyl may promote antidiuretic hormone release and urinary retention, which could blunt the diuretic effect of hydrochlorothiazide. Opioids can also add to the blood pressure lowering of antihypertensives, particularly at initiation or dose increases.
What this interaction means in plain words
Fentanyl transmucosal and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-related ADH release and urinary retention may oppose diuresis, while additive pharmacodynamic hypotensive effects may occur.
What to do
Monitor blood pressure, fluid status and urine output when starting or increasing fentanyl. Adjust antihypertensive or diuretic doses if hypotension or fluid retention develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Fentanyl transmucosal with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Fentanyl transmucosal and Fosinopril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids such as fentanyl may promote antidiuretic hormone release and urinary retention, which could blunt the diuretic effect of hydrochlorothiazide. Opioids can also add to the blood pressure lowering of antihypertensives, particularly at initiation or dose increases.
How serious is the interaction between Fentanyl transmucosal and Fosinopril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and urine output when starting or increasing fentanyl. Adjust antihypertensive or diuretic doses if hypotension or fluid retention develops.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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