Drug interactions
Fentanyl transmucosal + Guselkumab
Severity: Minor
Fentanyl transmucosal and Guselkumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reduced inflammation with guselkumab may restore CYP3A4 activity and lower fentanyl exposure. The effect is theoretical and likely small.
What this interaction means in plain words
Fentanyl transmucosal and Guselkumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Reduced cytokine-mediated suppression of CYP3A4 may increase fentanyl metabolism.
What to do
Monitor analgesic response when guselkumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Fentanyl transmucosal with Guselkumab?
MediHelp rates the interaction as minor. Fentanyl transmucosal and Guselkumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reduced inflammation with guselkumab may restore CYP3A4 activity and lower fentanyl exposure. The effect is theoretical and likely small.
How serious is the interaction between Fentanyl transmucosal and Guselkumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response when guselkumab is started or stopped.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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