Drug interactions
Fentanyl transmucosal + Levetiracetam
Severity: Moderate
Fentanyl transmucosal and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transmucosal fentanyl rapidly delivers a potent opioid with sedative and respiratory depressant effects, and levetiracetam can add drowsiness. Together they may increase excessive sedation.
What this interaction means in plain words
Fentanyl transmucosal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from an opioid and an antiepileptic.
What to do
Monitor for sedation and slowed breathing and use the lowest effective fentanyl dose. Counsel the patient on avoiding other depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Fentanyl transmucosal with Levetiracetam?
MediHelp rates the interaction as moderate. Fentanyl transmucosal and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transmucosal fentanyl rapidly delivers a potent opioid with sedative and respiratory depressant effects, and levetiracetam can add drowsiness. Together they may increase excessive sedation.
How serious is the interaction between Fentanyl transmucosal and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and slowed breathing and use the lowest effective fentanyl dose. Counsel the patient on avoiding other depressants.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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