Drug interactions
Ferrous fumarate + Vonoprazan
Severity: Moderate
Ferrous fumarate and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan produces profound and sustained gastric acid suppression, which can impair absorption of non-heme oral iron. Long-term use may lead to a reduced response to iron supplements or iron deficiency.
What this interaction means in plain words
Ferrous fumarate and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous fumarate belongs to Miscellaneous; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces dissolution of iron salts and the reduction of ferric to absorbable ferrous iron.
What to do
Monitor ferritin, transferrin saturation and hemoglobin during long-term co-therapy. Consider a higher iron dose, alternate-day dosing, or intravenous iron if oral therapy fails.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ferrous fumarate and Vonoprazan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ferrous fumarate
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Ferrous fumarate with Vonoprazan?
MediHelp rates the interaction as moderate. Ferrous fumarate and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan produces profound and sustained gastric acid suppression, which can impair absorption of non-heme oral iron. Long-term use may lead to a reduced response to iron supplements or iron deficiency.
How serious is the interaction between Ferrous fumarate and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ferritin, transferrin saturation and hemoglobin during long-term co-therapy. Consider a higher iron dose, alternate-day dosing, or intravenous iron if oral therapy fails.
What other medicines interact with Ferrous fumarate?
MediHelp also lists interactions of Ferrous fumarate with, for example, Ciprofloxacin, Acetohydroxamic acid, Aluminum hydroxide. The full list is on the Ferrous fumarate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
