Drug interactions
Ferrous sulfate + Trientine
Severity: Moderate
Ferrous sulfate and Trientine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron and trientine chelate each other in the gut, reducing absorption of both. Trientine efficacy in copper removal may drop, and the iron may be less effective as well.
What this interaction means in plain words
Ferrous sulfate and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous sulfate belongs to Miscellaneous; Trientine belongs to Miscellaneous.
Why it happens
Mutual chelation in the gastrointestinal tract forms poorly absorbed complexes.
What to do
Separate iron and trientine by at least 2 hours. Monitor copper indices in Wilson disease and iron indices.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous sulfate
Other interactions of Trientine
- Calcium + Trientine Moderate
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Iron + Trientine Moderate
Frequently asked questions
Can I take Ferrous sulfate with Trientine?
MediHelp rates the interaction as moderate. Ferrous sulfate and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron and trientine chelate each other in the gut, reducing absorption of both. Trientine efficacy in copper removal may drop, and the iron may be less effective as well.
How serious is the interaction between Ferrous sulfate and Trientine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate iron and trientine by at least 2 hours. Monitor copper indices in Wilson disease and iron indices.
What other medicines interact with Ferrous sulfate?
MediHelp also lists interactions of Ferrous sulfate with, for example, Ciprofloxacin, Dimercaprol, Acetohydroxamic acid. The full list is on the Ferrous sulfate page.
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