Drug interactions
Carbonyl iron + Trientine
Severity: Moderate
Carbonyl iron and Trientine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral iron and trientine chelate each other in the gut, reducing absorption of both and possibly weakening copper removal in Wilson disease. Iron-trientine complexes may also irritate the gut.
What this interaction means in plain words
Carbonyl iron and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbonyl iron belongs to Miscellaneous; Trientine belongs to Miscellaneous.
Why it happens
Trientine chelates iron in the gastrointestinal tract, forming poorly absorbed complexes.
What to do
Give iron at least 2 hours apart from trientine. Monitor copper and iron indices.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbonyl iron
- Aluminum hydroxide + Carbonyl iron Moderate
- Baloxavir marboxil + Carbonyl iron Moderate
- Calcium acetate + Carbonyl iron Moderate
- Calcium carbonate + Carbonyl iron Moderate
- Calcium + Carbonyl iron Moderate
- Carbidopa-entacapone-levodopa + Carbonyl iron Moderate
Other interactions of Trientine
- Calcium + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
- Iron + Trientine Moderate
Frequently asked questions
Can I take Carbonyl iron with Trientine?
MediHelp rates the interaction as moderate. Carbonyl iron and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron and trientine chelate each other in the gut, reducing absorption of both and possibly weakening copper removal in Wilson disease. Iron-trientine complexes may also irritate the gut.
How serious is the interaction between Carbonyl iron and Trientine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give iron at least 2 hours apart from trientine. Monitor copper and iron indices.
What other medicines interact with Carbonyl iron?
MediHelp also lists interactions of Carbonyl iron with, for example, Aluminum hydroxide, Baloxavir marboxil, Calcium acetate. The full list is on the Carbonyl iron page.
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