Drug interactions
Calcium + Trientine
Severity: Moderate
Calcium and Trientine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium supplements can bind trientine in the gut and reduce its absorption, potentially lessening copper removal.
What this interaction means in plain words
Calcium and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Trientine belongs to Miscellaneous.
Why it happens
Chelation of trientine by calcium reduces gastrointestinal absorption.
What to do
Separate dosing: trientine at least 1 hour before or 2 hours after calcium. Monitor copper indices.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium and Trientine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trientine
- Carbonyl iron + Trientine Moderate
- Copper + Trientine Moderate
- Ferrous fumarate + Trientine Moderate
- Ferrous gluconate + Trientine Moderate
- Ferrous sulfate + Trientine Moderate
- Iron + Trientine Moderate
Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Trientine?
MediHelp rates the interaction as moderate. Calcium and Trientine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium supplements can bind trientine in the gut and reduce its absorption, potentially lessening copper removal.
How serious is the interaction between Calcium and Trientine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing: trientine at least 1 hour before or 2 hours after calcium. Monitor copper indices.
What other medicines interact with Trientine?
MediHelp also lists interactions of Trientine with, for example, Carbonyl iron, Copper, Ferrous fumarate. The full list is on the Trientine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
