Drug interactions
Ferrous sulfate + Vonoprazan
Severity: Moderate
Ferrous sulfate and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a potent, long-lasting acid suppressant, which can reduce the absorption of oral iron salts. Prolonged use may lead to poorer response to iron therapy.
What this interaction means in plain words
Ferrous sulfate and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ferrous sulfate belongs to Miscellaneous; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Sustained rise in gastric pH decreases solubility and absorption of non-heme iron.
What to do
Monitor hemoglobin and ferritin during long-term combined use. Consider a higher iron dose or parenteral iron if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ferrous sulfate
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Ferrous sulfate with Vonoprazan?
MediHelp rates the interaction as moderate. Ferrous sulfate and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is a potent, long-lasting acid suppressant, which can reduce the absorption of oral iron salts. Prolonged use may lead to poorer response to iron therapy.
How serious is the interaction between Ferrous sulfate and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and ferritin during long-term combined use. Consider a higher iron dose or parenteral iron if the response is inadequate.
What other medicines interact with Ferrous sulfate?
MediHelp also lists interactions of Ferrous sulfate with, for example, Ciprofloxacin, Dimercaprol, Acetohydroxamic acid. The full list is on the Ferrous sulfate page.
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