Drug interactions
Fesoterodine + Griseofulvin
Severity: Minor
Fesoterodine and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of CYP3A4 and may lower exposure to the active metabolite of fesoterodine, 5-hydroxymethyl tolterodine. Reduced antimuscarinic effect may lead to poorer control of overactive bladder symptoms.
What this interaction means in plain words
Fesoterodine and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Griseofulvin belongs to Anti Fungals.
Why it happens
Weak induction of CYP3A4 by griseofulvin may increase the clearance of the fesoterodine active metabolite.
What to do
No routine dose change is required; assess bladder symptom control and increase the fesoterodine dose within labeled limits if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Griseofulvin
Frequently asked questions
Can I take Fesoterodine with Griseofulvin?
MediHelp rates the interaction as minor. Fesoterodine and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak inducer of CYP3A4 and may lower exposure to the active metabolite of fesoterodine, 5-hydroxymethyl tolterodine. Reduced antimuscarinic effect may lead to poorer control of overactive bladder symptoms.
How serious is the interaction between Fesoterodine and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; assess bladder symptom control and increase the fesoterodine dose within labeled limits if the response is inadequate.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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