Drug interactions
Fesoterodine + Imipramine
Severity: Moderate
Fesoterodine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine has strong anticholinergic properties, and combining it with fesoterodine increases antimuscarinic adverse effects. Patients may develop marked dry mouth, constipation, urinary retention, tachycardia, blurred vision, or confusion.
What this interaction means in plain words
Fesoterodine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Imipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects at muscarinic receptors.
What to do
Monitor for anticholinergic toxicity, especially urinary retention and cognitive effects in older patients. Consider a less anticholinergic antidepressant if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Fesoterodine with Imipramine?
MediHelp rates the interaction as moderate. Fesoterodine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine has strong anticholinergic properties, and combining it with fesoterodine increases antimuscarinic adverse effects. Patients may develop marked dry mouth, constipation, urinary retention, tachycardia, blurred vision, or confusion.
How serious is the interaction between Fesoterodine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially urinary retention and cognitive effects in older patients. Consider a less anticholinergic antidepressant if symptoms emerge.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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