Drug interactions
Fesoterodine + Miconazole
Severity: Minor
Fesoterodine and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fesoterodine is converted to the active 5-hydroxymethyl tolterodine, which is cleared by CYP3A4 and CYP2D6. Miconazole can raise active metabolite levels, increasing anticholinergic effects. Vaginal use leads to only a small effect.
What this interaction means in plain words
Fesoterodine and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, reducing clearance of the active metabolite of fesoterodine.
What to do
No adjustment is usually needed with vaginal miconazole. Monitor for dry mouth, constipation and urinary retention; limit fesoterodine to 4 mg daily if systemic azole therapy is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Miconazole?
MediHelp rates the interaction as minor. Fesoterodine and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fesoterodine is converted to the active 5-hydroxymethyl tolterodine, which is cleared by CYP3A4 and CYP2D6. Miconazole can raise active metabolite levels, increasing anticholinergic effects. Vaginal use leads to only a small effect.
How serious is the interaction between Fesoterodine and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed with vaginal miconazole. Monitor for dry mouth, constipation and urinary retention; limit fesoterodine to 4 mg daily if systemic azole therapy is used.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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