Drug interactions
Fesoterodine + Nelfinavir
Severity: Moderate
Fesoterodine and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and raises exposure to the active metabolite of fesoterodine. Labeling recommends limiting the fesoterodine dose with potent CYP3A4 inhibitors because of increased anticholinergic adverse effects.
What this interaction means in plain words
Fesoterodine and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of the active metabolite of fesoterodine.
What to do
Limit fesoterodine to 4 mg daily with potent CYP3A4 inhibitors. Monitor for anticholinergic effects and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fesoterodine with Nelfinavir?
MediHelp rates the interaction as moderate. Fesoterodine and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and raises exposure to the active metabolite of fesoterodine. Labeling recommends limiting the fesoterodine dose with potent CYP3A4 inhibitors because of increased anticholinergic adverse effects.
How serious is the interaction between Fesoterodine and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit fesoterodine to 4 mg daily with potent CYP3A4 inhibitors. Monitor for anticholinergic effects and urinary retention.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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