Drug interactions
Fesoterodine + Neostigmine
Severity: Moderate
Fesoterodine and Neostigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neostigmine increases cholinergic activity while fesoterodine blocks muscarinic receptors, so each may reduce the effect of the other. The antimuscarinic may diminish the intended muscarinic effects of neostigmine, such as bladder or bowel stimulation.
What this interaction means in plain words
Fesoterodine and Neostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Neostigmine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between a cholinesterase inhibitor and a muscarinic antagonist.
What to do
Monitor for reduced efficacy of either drug, for example bladder or gastrointestinal symptoms. Avoid combining when possible, or adjust doses according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Neostigmine
Frequently asked questions
Can I take Fesoterodine with Neostigmine?
MediHelp rates the interaction as moderate. Fesoterodine and Neostigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neostigmine increases cholinergic activity while fesoterodine blocks muscarinic receptors, so each may reduce the effect of the other. The antimuscarinic may diminish the intended muscarinic effects of neostigmine, such as bladder or bowel stimulation.
How serious is the interaction between Fesoterodine and Neostigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced efficacy of either drug, for example bladder or gastrointestinal symptoms. Avoid combining when possible, or adjust doses according to clinical response.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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