Drug interactions
Fesoterodine + Nifedipine
Severity: Minor
Fesoterodine and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is a substrate of CYP3A4 and not a meaningful inhibitor, so a clinically relevant increase in fesoterodine exposure is unlikely. Both drugs can affect smooth muscle, and the combination may modestly alter bladder or bowel function.
What this interaction means in plain words
Fesoterodine and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fesoterodine belongs to Genitourinary; Nifedipine belongs to Cardiovascular.
Why it happens
No established pharmacokinetic mechanism; theoretical weak CYP3A4 competition.
What to do
No dose adjustment is needed; monitor for constipation and urinary symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fesoterodine
Other interactions of Nifedipine
Frequently asked questions
Can I take Fesoterodine with Nifedipine?
MediHelp rates the interaction as minor. Fesoterodine and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is a substrate of CYP3A4 and not a meaningful inhibitor, so a clinically relevant increase in fesoterodine exposure is unlikely. Both drugs can affect smooth muscle, and the combination may modestly alter bladder or bowel function.
How serious is the interaction between Fesoterodine and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for constipation and urinary symptoms.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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