Drug interactions
Fesoterodine + Nilotinib
Severity: Moderate
Fesoterodine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may increase exposure to the active metabolite of fesoterodine, raising antimuscarinic effects. Both drugs can also affect cardiac conduction, since nilotinib prolongs the QT interval and antimuscarinics may raise heart rate.
What this interaction means in plain words
Fesoterodine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Nilotinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by nilotinib reduces clearance of the fesoterodine active metabolite.
What to do
Monitor for antimuscarinic adverse effects and limit fesoterodine to 4 mg daily if they occur. Follow the usual ECG monitoring for nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Fesoterodine with Nilotinib?
MediHelp rates the interaction as moderate. Fesoterodine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may increase exposure to the active metabolite of fesoterodine, raising antimuscarinic effects. Both drugs can also affect cardiac conduction, since nilotinib prolongs the QT interval and antimuscarinics may raise heart rate.
How serious is the interaction between Fesoterodine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for antimuscarinic adverse effects and limit fesoterodine to 4 mg daily if they occur. Follow the usual ECG monitoring for nilotinib.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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