Drug interactions
Fesoterodine + Oxybutynin
Severity: Moderate
Fesoterodine and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic agents for overactive bladder, so combining them duplicates therapy and increases dry mouth, constipation, blurred vision, urinary retention and cognitive effects without a well-established benefit.
What this interaction means in plain words
Fesoterodine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Oxybutynin belongs to Genitourinary.
Why it happens
Therapeutic duplication with additive muscarinic receptor blockade.
What to do
Avoid using two antimuscarinic bladder agents together; optimize one drug or switch class. If combined, monitor for retention and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Fesoterodine
Frequently asked questions
Can I take Fesoterodine with Oxybutynin?
MediHelp rates the interaction as moderate. Fesoterodine and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic agents for overactive bladder, so combining them duplicates therapy and increases dry mouth, constipation, blurred vision, urinary retention and cognitive effects without a well-established benefit.
How serious is the interaction between Fesoterodine and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antimuscarinic bladder agents together; optimize one drug or switch class. If combined, monitor for retention and anticholinergic effects.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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