Drug interactions
Fesoterodine + Rifabutin
Severity: Moderate
Fesoterodine and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower levels of the active metabolite of fesoterodine, reducing efficacy.
What this interaction means in plain words
Fesoterodine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fesoterodine belongs to Genitourinary; Rifabutin belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by rifabutin increases clearance of the active metabolite of fesoterodine.
What to do
Monitor for loss of symptom control and increase fesoterodine to the labeled maximum if needed, or select another agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Fesoterodine with Rifabutin?
MediHelp rates the interaction as moderate. Fesoterodine and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may lower levels of the active metabolite of fesoterodine, reducing efficacy.
How serious is the interaction between Fesoterodine and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and increase fesoterodine to the labeled maximum if needed, or select another agent.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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