Drug interactions
Feverfew + Indomethacin
Severity: Moderate
Feverfew and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew has antiplatelet activity and indomethacin impairs platelet function while also irritating the gastric mucosa. Used together they may raise the risk of bruising and gastrointestinal or other bleeding.
What this interaction means in plain words
Feverfew and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of platelet aggregation through prostaglandin and other pathways.
What to do
Advise patients to report bleeding, black stools or easy bruising, and consider stopping feverfew if bleeding signs develop. Avoid the combination in patients with a history of GI bleeding or on anticoagulants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Feverfew with Indomethacin?
MediHelp rates the interaction as moderate. Feverfew and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew has antiplatelet activity and indomethacin impairs platelet function while also irritating the gastric mucosa. Used together they may raise the risk of bruising and gastrointestinal or other bleeding.
How serious is the interaction between Feverfew and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report bleeding, black stools or easy bruising, and consider stopping feverfew if bleeding signs develop. Avoid the combination in patients with a history of GI bleeding or on anticoagulants.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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