Drug interactions
Feverfew + Ketoprofen
Severity: Moderate
Feverfew and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew has antiplatelet activity in vitro and may add to the platelet inhibition and gastrointestinal bleeding risk of ketoprofen. Clinical evidence of actual bleeding is limited.
What this interaction means in plain words
Feverfew and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of platelet aggregation, with feverfew constituents reducing platelet secretion and prostaglandin synthesis.
What to do
Advise patients to report bruising, black stools or other bleeding, and consider stopping feverfew while taking NSAIDs, especially before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Feverfew with Ketoprofen?
MediHelp rates the interaction as moderate. Feverfew and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew has antiplatelet activity in vitro and may add to the platelet inhibition and gastrointestinal bleeding risk of ketoprofen. Clinical evidence of actual bleeding is limited.
How serious is the interaction between Feverfew and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report bruising, black stools or other bleeding, and consider stopping feverfew while taking NSAIDs, especially before surgery.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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