Drug interactions
Feverfew + Oxaprozin
Severity: Moderate
Feverfew and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew inhibits platelet aggregation in laboratory studies and may increase bleeding tendency when combined with NSAIDs. Clinical reports are limited.
What this interaction means in plain words
Feverfew and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Parthenolide and related constituents inhibit platelet function, adding to the antiplatelet effect of oxaprozin.
What to do
Advise avoiding feverfew supplements during oxaprozin therapy, and stop it before surgery. Monitor for bruising or bleeding if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Feverfew with Oxaprozin?
MediHelp rates the interaction as moderate. Feverfew and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew inhibits platelet aggregation in laboratory studies and may increase bleeding tendency when combined with NSAIDs. Clinical reports are limited.
How serious is the interaction between Feverfew and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding feverfew supplements during oxaprozin therapy, and stop it before surgery. Monitor for bruising or bleeding if used together.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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