Drug interactions
Feverfew + Sulindac
Severity: Moderate
Feverfew and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew has antiplatelet activity in laboratory studies, and sulindac also impairs platelet function and irritates the gastric mucosa. Taken together they may increase the risk of bruising and bleeding.
What this interaction means in plain words
Feverfew and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of platelet function, with feverfew inhibiting platelet aggregation and sulindac inhibiting cyclooxygenase.
What to do
Advise patients to avoid feverfew while taking sulindac, or monitor for bleeding if both are used. Stop feverfew before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Feverfew with Sulindac?
MediHelp rates the interaction as moderate. Feverfew and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew has antiplatelet activity in laboratory studies, and sulindac also impairs platelet function and irritates the gastric mucosa. Taken together they may increase the risk of bruising and bleeding.
How serious is the interaction between Feverfew and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid feverfew while taking sulindac, or monitor for bleeding if both are used. Stop feverfew before surgery.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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