Drug interactions
Fexinidazole + Flecainide
Severity: Major
Fexinidazole and Flecainide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole is associated with QT prolongation and its labeling advises against combining it with other QT-prolonging drugs. Flecainide adds conduction slowing, so the risk of serious arrhythmia increases.
What this interaction means in plain words
Fexinidazole and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction.
What to do
Avoid the combination. If fexinidazole is essential, temporarily replace flecainide with a non-QT-prolonging alternative and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Fexinidazole with Flecainide?
MediHelp rates the interaction as major. Fexinidazole and Flecainide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole is associated with QT prolongation and its labeling advises against combining it with other QT-prolonging drugs. Flecainide adds conduction slowing, so the risk of serious arrhythmia increases.
How serious is the interaction between Fexinidazole and Flecainide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If fexinidazole is essential, temporarily replace flecainide with a non-QT-prolonging alternative and correct hypokalemia and hypomagnesemia.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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