Drug interactions
Fexinidazole + Flutamide
Severity: Moderate
Fexinidazole and Flutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and could increase exposure to flutamide. Both drugs can affect the liver, and fexinidazole is also associated with QT prolongation and hepatic effects.
What this interaction means in plain words
Fexinidazole and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by fexinidazole may reduce flutamide clearance, with possible additive hepatotoxicity.
What to do
Avoid coadministration where an alternative exists; if needed, monitor liver enzymes closely during the short fexinidazole course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Frequently asked questions
Can I take Fexinidazole with Flutamide?
MediHelp rates the interaction as moderate. Fexinidazole and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and could increase exposure to flutamide. Both drugs can affect the liver, and fexinidazole is also associated with QT prolongation and hepatic effects.
How serious is the interaction between Fexinidazole and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where an alternative exists; if needed, monitor liver enzymes closely during the short fexinidazole course.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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